2,5-difluorophenacyl chloride

2,5-difluorophenacyl chloride - Names and Identifiers

Name	2,5-difluorophenacyl chloride
Synonyms	2,5-difluorophenacyl chloride 2-CHLORO-2,5-DIFLUOROACETOPHENONE 2-Chloro-2,5-difluoroacetophenone 2-Chloro-2',5-difluoroacetophenone 2-CHLORO-2',5'-DIFLUOROACETOPHENONE 2-Chloro-2',5'-Difluoroacetophenone 2-chloro-1-(2,5-difluorophenyl)ethanone 2-chloro-1-(2',5'-difluorophenyl)ethanone Ethanone, 2-chloro-1-(2,5-difluorophenyl)- 2-chloro-1-(2,5-difluorophenyl)ethanone 1-chloro-3-fluoro-2-[(Z)-2-nitrovinyl]benzene 2,5-difluorophenacyl chloride ,2-chloro-1-(2,5-difluorophenyl)ethanone 2-Chloro-1-(2,5-difluorophenyl)ethanone[2-Chloro-2',5'-difluoroacetophenone]
CAS	60468-36-2
InChI	InChI=1/C8H5ClFNO2/c9-7-2-1-3-8(10)6(7)4-5-11(12)13/h1-5H/b5-4-

2,5-difluorophenacyl chloride - Physico-chemical Properties

Molecular Formula	C8H5ClF2O
Molar Mass	190.57
Density	1.353±0.06 g/cm3(Predicted)
Melting Point	49-50 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boling Point	240.5±25.0 °C(Predicted)
Flash Point	127.4°C
Vapor Presure	0.00441mmHg at 25°C
Appearance	Solid
Storage Condition	Room Temprature
Refractive Index	1.593

2,5-difluorophenacyl chloride - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

2,5-difluorophenacyl chloride - Reference Information

Introduction

the derivatives of difluoro-arene are important intermediates in the synthesis of new and efficient fluorine-containing pesticides and medicines, has very broad application value. The study of its synthesis is one of the hot topics in organic synthesis, which has attracted wide attention. 2-chloro-2 ',5'-difluoroacetophenone is an important intermediate in organic synthesis, which is widely used in medicine, pesticide and chemical industry.

preparation

A preparation method of 2-chloro-2 ',5'-difluoroacetophenone is provided, which comprises the following steps: a, fluorobenzene and Chloroacetyl Chloride are reacted in ionic liquid to obtain 2-chloro-2 ',5'-difluoroacetophenone; B, after the reaction is complete, by distillation, 2-chloro-4 '-fluoroacetophenone was isolated directly from the reaction solution. In the above preparation method of 2-chloro-2 ',5'-difluoroacetophenone, the reaction temperature in Step a is 0-30 °c. In the above preparation method of 2-chloro-2 ',5'-difluoroacetophenone, the molar ratio of fluorobenzene to Chloroacetyl Chloride in Step a is 1.01-1.03: 1. In the preparation method of 2-chloro-2 ',5'-difluoroacetophenone, the molar ratio of the ionic liquid to Chloroacetyl Chloride in Step a is 0.5: 1. In the above preparation method of 2-chloro-2 ',5'-difluoroacetophenone, the reaction described in step B is completely such that the conversion rate of fluorobenzene is more than 95%. The reaction time at room temperature of about 25 ° C. Is usually 30 minutes. If the temperature is lowered, the reaction time may be appropriately prolonged.

Last Update：2024-04-09 02:00:02